ABSTRACT
Objective: The purpose of this study is to estimate the diagnostic efficacy of VIA (Visual Inspection after Acetic Acid) and VILI (Visual Inspection with Lugol's Iodine) and to investigate the strength of the correlation between VIA, VILI, and colposcopic examination using Reid Colposcopic Index (RCI) and histopathology.
Methods: Two-hundred women aged 19-72 who underwent colposcopy because of abnormal pap-smear, were included in the study. All women underwent cervical examination, VIA and VILI practices and colposcopy, respectively. Primarily, the first gynecologist (N.V.T) used both VIA and VILI to take samples from visually abnormal areas. Then, the second gynecologist (F.K) who was blinded to the results of first exam performed colposcopy and took biopsy samples from the suspicious areas on colposcopy. Four-quadrant biopsies were taken when there were no abnormal findings on the colposcopic examination.
Results: There were 72 (36%) histopathologically abnormal sample in 200 biopsies. The sensitivity and specificity of VIA test for predicting abnormal cervical biopsies were 51.4% and 57% and 59.7% and 63.3% for VILI test, respectively. When these two methods were combined, the sensitivity and specificity were 71% and 47% respectively.
Conclusion: Although the sensitivity and the specificity of VIA and VILI in our study were lower than previous studies we think that these tests can be used as an alternative when colposcopy is unavailable. In addition, it can be convenient alternative method that is inexpensive and easy to apply and even suitable for “See and Treat” approach.
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