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Antineutrophil Cytoplasmic Antibody-negative Pauci-immune Crescentic Glomerulonephritis and Mantle-cell Lymphoma: A Case Report and Review of the Literature

Issue: 
DOI: 
10.7727/wimjopen.2014.198
Pages: 
114–6

ABSTRACT

Mantle-cell lymphoma (MCL) is an aggressive lymphoid neoplasm of non-Hodgkin's lymphoma (NHL). Crescentic glomerulonephritis associated with NHL has rarely been reported. In this report, we present a case of antineutrophil cytoplasmic antibody (ANCA)-negative pauci-immune crescentic glomerulonephritis (GN), presenting with the coexistence of proteinuria, haematuria, progressive renal failure and MCL infiltration in the kidney, in the setting of newly-diagnosed MCL. Following the chemotherapy, there was a resolution of renal function. To the best of our knowledge, this is the first report of ANCA-negative pauci-immune crescentic GN and MCL. The pathophysiologic relationship between ANCA-negative pauci-immune crescentic GN and MCL should be investigated further. 

*contributed equally to the manuscript  

 

Accepted: 
September 8, 2014
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