Comprehensive treatments for visceral metastatic carcinoma of unknown primary site (VMCUP) including surgery and chemotherapy significantly improved patients’ overall survival time. Patients treated mainly by surgery lived longer than those treated by chemotherapy alone. More chemotherapy cycles resulted in longer survival time for patients only receiving chemotherapy. For the first time, this study identified paclitaxel plus fluorouracil as more effective first-line chemotherapy drugs than 5-fluorouracil in treating VMCUP.
HIV-positive women enrolled in the Prevention of Mother to Child Transmission (PMTCT) programme in Trinidad and Tobago did not use family planning services, had unplanned pregnancies, and felt stigmatized when pregnant. Integrated treatment, family planning and PMTCT services can help HIV-positive women and their partners safely achieve their reproductive goals.
Compelling evidence proves that bronchial smooth muscle mass significantly increases in asthmatics, and chronic formoterol administration induces impaired bronchoprotection. No significant difference was detected in increased smooth muscle mass, implying that some other molecular mechanisms might be involved.
Multidrug resistance is a major obstacle in the success of cancer chemotherapy. Recent studies have focussed on plant extracts to reverse drug resistance. This study evaluates the efficacy of Momordica charantia extract in reversing drug resistance in small cell carcinoma cell lines.
In this study of cancer mortality in Antigua and Barbuda, gender-specific cancers accounted for approximately half of the cancer deaths. Mortality/incidence ratios greater than 1 suggest that there may be incomplete data capture of the incidence.
MA Harris, K James, NK Waldron, TS Ferguson, JP Figueroa
The quality of care received by patients with diabetes in public primary care clinics in 2012 was compared with that received in 1995. There was improvement in the screening, monitoring and counselling of patients in 2012 compared to 1995. However, there was no improvement in glycaemic control.
Endowashers can be a potential source of infection in post-endoscopic procedures. Routine checking of the water samples for quality control of endowashers should be done to monitor the spread of nosocomial infections by potentially resistant bacteria.
We report on a rare case of antineutrophil cytoplasmic antibody (ANCA)-negative pauci-immune crescentic glomerulonephritis (GN) probably due to mantle-cell lymphoma (MCL). Chemotherapy may improve the outcome. The pathophysiologic relationship between ANCA-negative pauci-immune crescentic GN and MCL should be investigated further.
West Indian Medical Journal
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