This study aimed to evaluate the role of hepatectomy in the treatment of hepatolithiasis. One hundred and forty-seven patients with hepatolithiasis were subjected to hepatectomy and preoperative evaluation for hepatolithiasis typing. In 108 cases, the hepatectomy was left hepatic lobectomy and in 30 cases, it was right hepatic lobectomy. There were 17 cases of multiple segmental resections. The stone clearance was 85% (125/147). Residual stones were removed through the T-tube sinus postoperatively, and the final stone clearance was 95.9% (141/147). There were 28 cases (19.1%) of postoperative complications, including temporary biliary fistula, resectional surface and subphrenic infection and haematobilia. Hepatic lobectomy was an effective method in the treatment of hepatolithiasis.