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Correlation between Expression of Ki67 with Her-2 and p53 Tumour Markers in Breast Cancer Patients

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Introduction: Breast cancer is the most common cancer in women. The importance of several molecular markers in breast cancer has generated interest in recent years. The assessment of biomarkers such as Ki67, Her-2 and P53 can be valuable in predicting the outcomes of diseases and decision-making for their optimal treatment. The purpose of this study is to investigate the relationships among Ki67, Her-2 and P53 tumour markers in breast cancer patients.
Subjects and methods: In this study, 184 breast cancer patients were chosen. Immunohistochemistry technique was used for detecting the expressions of Ki67, Her-2 and P53 proteins in breast cancer patients. For the correlations among the parameters, Fisher exact test and Spearman’s rho were used. In all the tests, the p-value was considered significant if it were less than 0.05.
Results: In this study, Ki67 positive, P53 and Her-2 positive, were found, respectively in 53.2%, 38.5% and 54.6 % of the patients. There was a significant relationship between Ki67 and P53 (p < 0.05). But, there were no relationships among Ki67 and Her-2 and the clinicopathological parameters (p > 0.05).
Conclusion: Breast cancer progression is often associated with the alterations in the expressions of Ki67, P53 and Her-2 tumour markers. These changes may affect the treatment decisions. Also, the significant relationship between Ki67 and P53 protein showed that cell proliferation may be related to the over-expression of P53 protein in breast cancer patients.


16 Mar, 2015
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e-Published: 11 May, 2015
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