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Cd40-Cd40 Ligand System and P-selectin as Early Markers for Detection of Pre-eclampsia

Objectives: Pre-eclampsia is a most important health distress, as it is a principal cause of maternal and fetal mortality and morbidity, all over the world. The aim of this work was to assess the presence of inflammatory and thrombotic response during pre-eclampsia by demonstrating CD40-CD40 ligand and P-selectin in pre-eclamptic pregnant women. 
Methods: The study included 81 pregnant women divided into three groups, group I; 39 pregnant women with mild pre-eclampsia, group II; 22 women with severe pre-eclampsia and group III; 20 apparently healthy pregnant women. All groups were subjected to; complete clinical examination, prothrombin time and concentration, urea, creatinine, urinary protein, CBC, expression of CD40 on monocytes, sCD40L and P-selectin.
Results: There was a statistically significant higher expression of CD40 on monocytes, sCD40lLand P-selectin in the pregnant women with mild and severe pre-eclampsia compared with normotensive pregnant women (p < 0.001). The most sensitive marker was share of sCD40L while the highest specificity was the expression of CD40 on monocytes.
Conclusion: The study show presence of activation of the CD40–CD40L system and elevated level of P-selectin in women with pre-eclampsia - whether mild or sever types. Using of such markers may be essential for developing better prediction polices as well as for affecting patient treatment decision forward and improving patient outcome for both babies and mothers suffering from pre-eclampsia.
05 Jan, 2015
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e-Published: 26 May, 2015
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