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Study pertaining to the Hypothermic Activity of Plumeria rubra, Linn. in PGE1 and TAB-Vaccine Induced Pyrexia Models in Rabbits



Objective: Plumeria rubra, Linn is a potent medicinal plant in the global systems of medicine. The objective of the present work was to study the antipyretic activity of the plant: Plumeria rubra, Linn is belonging to the family Apocynaceae.

Materials and Methods: In the present study the methanolic extracts of the bark of Plumeria rubra, Linn were studied for their antipyretic activity by typhoid (TAB) vaccine and PGE1 (Prostaglandin E) induced pyrexia in rabbits.

Result: In TAB vaccine-induced fever, the fever was significantly reduced and the body temperature was normalized by administration of 100 and 200 mg/kg dose orally and the hypothermic property was comparable to the reference drug (paracetamol). On the other hand, pyrexia induced by PGE1 was significantly reduced as compared to the standard drug (aspirin).

Conclusion: This study has established the hypothermic activity of Plumeria rubra, Linn and thus, justifies the anecdotal, folkloric and ethnomedical uses of this plant for fever.

25 Mar, 2015
e-Published: 13 Aug, 2015


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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