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Application of Modified Glomerular Filtration Rate Estimation Equations in Chinese Diabetic Patients with Chronic Kidney Diseases

Journal Authors: 
Objective: To evaluate the applicability of modified formulae based on plasma creatinine levels in Chinese diabetic patients with chronic kidney diseases (CKD).
Methods: A total of 294 diabetic patients were investigated. Glomerular filtration rate (GFR) was estimated with the Ruijin equation, Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulae. The accuracy of estimated GFR was compared with technetium-99m diethylene triamine pentaacetic acid (99mTc-DTPA)-GFR (sGFR).
Results: Bland-Altman analysis demonstrated that the Ruijin equation was more consistent with sGFR than the other equations. However, all the equations were not very consistent with sGFR. The analysis showed that the slope of the Ruijin equation was closer to the identical line and indicated that the bias of Ruijin equation was lowest. The 15%, 30% and 50% accuracies of the Ruijin equation were higher than those of the other equations; the 30% accuracy of Ruijin equation was more than 70%. 
Conclusions: Ruijin equation is more applicable in Chinese diabetic and CKD patients.
31 Oct, 2014
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e-Published: 14 Sep, 2015
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