ABSTRACT
Objective: To survey the effects of hypoxia on autophagy in the pulmonary encephalopathy.
Patients and Methods: A study on 50 patients of COPD complicated by pulmonaryencephalopathy (experimental group) and 50 patients of COPD without pulmonary encephalopathy (controls group). Cerebrospinal fluid of patients with lumbar puncture is acquired, β-glucocerebrosidase enzyme, ATG protein concentration were detected by ELISA and P62 protein concentration was detected by Western Blot.
Result: The results showed that the expression of the concentration of ATG7 protein and P62 protein and the β- glucocerebrosidase enzyme in patients of COPD complicated by pulmonary encephalopathy was significantly higher than those of patients without pulmonary encephalopathy.
Conclusion: This study suggested that autophagy in the central neuronal system of patients with pulmonary encephalopathy enhanced. So we can observe neuron autophagy in the pulmonary encephalopathy induced by hypoxia, and accumulate information for the prevention and treatment of pulmonary encephalopathy.
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