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Long-term Effect of Gestatıonal Age and Bırth Weıght on Macular Development



Objective:To evaluate macular structure in childhood due to their birth history, and analyse possible effects of prematurity and birth weight for gestatinonal age.

Design:A cohort, case-control study.

Methods: Children who were between 5 and 18 years old age were divided into the following 3 groups due to their birth histories: Patients who were preterm (Preterm: Group 1), full-term and small for gestational age (Full-term-SGA: Group 2), and full-term and average for gestational age (Full-term-AGA: Group 3,Control group). 398 eyes of 199 children were included. Their macular parameters were analysed by spectral-domain optical coherence tomography (SD-OCT). Mean outcome measures were central foveal thickness (CFT), minumum foveal thickness (MFT), inner retinal thickness (IRT), outer retinal thickness (ORT), central foveal volume (CFV), total macular volume (TMV), and parafoveal volume (PV).

Results: There was no statistically significant difference in age between the groups. The mean gestational age was 30,68±2,76; 38,82±0,75; and 39,59±0,56 weeks in Group 1, 2, and 3, respectively.

The mean CFT and MFT in Group 1 were significantly thicker than Group 1 (p=0.020, p=0,017). The mean IRT in Group 3 was significantly thicker than Group 1 (p=0.034;) and Group 2 (p=0.013). There was no statistically significant difference between the groups according to CFV, TMV, and PV.

Conclusions: Prematurity might be more associated with thicker CFT than small for gestational age, whereas both parameters seem to be associated with thinner parafoveal thickness in childhood.


02 Mar, 2015
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e-Published: 15 Oct, 2015


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