ABSTRACT
Objective: This study aimed to perform the carotid artery stretching experiments with young and elderly corpse for the study of carotid atherosclerosis pathogenesis and biomechanical basis.
Methods: 15 carotid arteries were randomly selected from young and elderly groups, respectively, for the longitudinal tensile test, and 1 specimens of each group was randomly selected for the morphological observation.
Results: The maximum longitudinal tensile stress, maximum strain, elastic limit strain of middle cerebral artery in young group were greater than those of elderly group (P < 0.05), while the elastic modulus of middle cerebral artery in young group was less than that of elderly group (P < 0.05). SEM results showed that the muscle cells of middle cerebral artery in young group were in neat arrangement, with intact elastic membrane, while the muscle cells of elderly carotid artery showed active hyperplasia, some elastic membrane were ruptured, with disorganized arrangement.
Conclusions: The morphology and longitudinal tensile properties of carotid artery in elderly group of changed.
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