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A Significant Association in Paediatric Emergency Department between Cerebral Sinovenous Thrombosis and Ulcerative Colitis: A Review of the Literature



 Aim: To discuss cerebral sinovenous thrombosis (CSVT), which is an important mortality and morbidity factor developing in progression of ulcerative colitis (UC) in childhood age, in the light of literature.

Materials and Methods: A review has been performed on database of Pubmed and Google Scholar Search on April 2014. The study retrospectively investigated the cases diagnosed UC with complication of CSVT below 18 years of age between years 1971 to 2014. The cases were analysed with respect to age, gender, disease duration and treatment, potential risk factors, clinical findings, location of thrombosis, thrombolytic therapeutical applications and clinical progressions.

Results: Twenty four paediatric cases aged between five and 18 years were included in the study. Cerebral sinovenous thrombosis had developed during active disease period in 23 (95.8%) periods. The most common application rationales were headache (79.1%) and emesis (29.1%). The most frequently detected risk factors for CSVT were anaemia (58.3%) and thrombocytosis (45.8%). Inherited thrombotic disorders were encountered 10 (41.6%) cases. The most common location sites for CSVT were transverse (33.3%) and sigmoid (33.3%) sinuses. It has been encountered that 19 (79.2%) cases were healed completely without a sequela whereas neurological sequelae remained in 3 (12.5%) cases and 2 (8.3%) cases died.

Conclusion: When a paediatric patient diagnosed with UC within apply emergency service with emesis, headache and mood changes during especially seizure; presence of CSVT should be certainly considered. 

30 Jun, 2015
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e-Published: 18 Dec, 2015


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