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Vitamins A, D and E in Primary Immunodeficiencies



Background: A,D and E vitamins have a very important role in humoral and cellular immunity.

Objective: The aim of this study was to compare serum levels of these vitamins in patients with various Primary immunodeficiency diseases (PIDs) and healthy controls.

Materials and methods: Thirty patients with PID and 21 sex- and age-matched healthy controls were enrolled into the study. IgG, IgA and IgM levels, lymphocyte subsets, serum vitamin A, D, and E levels were measured.

Results: Significantly decreased levels of vitamin-A and -E were found in the sera of all patients with PID compared to healthy controls. Serum levels of vitamin-A and -E were also lower in both PID subgroups than those of healthy controls. With respect to the levels of vitamin-D, no significant differences were observed in the comparisons of study groups. Serum vitamin A levels in patients with PID were positively correlated with serum vitamin E levels, respectively. There was no significant correlation among the measured vitamins in patient subgroups and healthy controls.

Discussion: The present study indicated that patients with PID have low serum levels of vitamins A and E. There was not any difference with respect to the serum vitamin D levels between patients with PID and healthy controls. Our patients with PID, decreased serum vitamin A levels were positively correlated with decreased IgG levels. However, there was no significant relationship among their immunological parameters and vitamin E levels. In conclusion, vitamin-A and -E deficiencies associate to a considerable subgroups of PID.

11 Jan, 2016
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e-Published: 23 Feb, 2016


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