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Tigecycline-induced Hypofibrinogenaemia in a Patient with End-stage Renal Diseases

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Tigecycline is a broad-spectrum antibiotic agent used to treat severe or multidrug-resistant (MDR) bacterial infections. Bacterial infection is a common and severe complication or co-morbidity associated with end-stage renal disease (ESRD). However, few cases have been reported regarding the adverse drug reaction of tigecycline in patients with ESRD. Here, we detail the case of a 19-year-old female with ESRD, who received tigecycline to treat sepsis due to a MDR Staphylococcus aureus. Following seven days of tigecycline, the patient developed coagulopathy with hypofibrinogenaemia, although there was no subsequent haemorrhage. The hypofibrinogenaemia resolved within 14 days after discontinuation of tigecycline. Therefore, we recommend that clinicians strictly monitor coagulation parameters in patients with ESRD during tigecycline treatment.

11 Sep, 2015
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e-Published: 08 Mar, 2016


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