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Role of TMPRSS2-ERG Fusions in Prostate Cancer: Significance of Assessment in Jamaican Men

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Prostate cancer is the leading cancer affecting men in Jamaica and is also the leading cause of male cancer-related deaths in Jamaica. This high mortality rate is primarily attributable to the eventual development of metastatic castration resistant prostate cancer which is challenging to treat. This paper discusses the pathological roles of   the TMPRSS2 and ERG genes which are highly expressed in prostate cancer when compared to other cancer types. The  presence of the TMPRSS2-ERG gene fusion transcript   is linked to progression, metastasis and androgen regulated changes in castration resistant prostate cancer; but the  status of these biomarkers have not been previously evaluated in Jamaican  men with prostate cancer. The significance and implications of such an assessment is discussed herein.

07 Dec, 2015
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e-Published: 29 Mar, 2016


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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