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Role of TMPRSS2-ERG Fusions in Prostate Cancer: Significance of Assessment in Jamaican Men

DOI: 
10.7727/wimj.2015.574
Synopsis: 
The role of the TMPRSS2-ERG fusion transcript in promoting prostate cancer progression and aggressiveness is discussed. The relevance of assessing the status of the transcript in Jamaican men with prostate cancer is also explored.

ABSTRACT

Accepted: 
07 Dec, 2015
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e-Published: 29 Mar, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

A Potential Role for the Antidiabetic Drug Metformin in the Treatment of Platinum Resistant Ovarian Cancer

Issue: 
DOI: 
10.7727/wimj.2015.456
Pages: 
674–78
Synopsis: 
The ability of metformin to enhance the cytotoxic profile of carboplatin in platinum resistant OVCAR3 ovarian cancer cells was evaluated alone and in the presence of the FAK inhibitor PF-5733228. Metformin significantly increased OVCAR3 sensitivity to both carboplatin and PF-573228.

ABSTRACT

Accepted: 
08 Sep, 2015
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e-Published: 12 Feb, 2016

Vitamin E and Focal Adhesion Kinase Inhibitor Y15 Enhances the Cytotoxic Effects of Cisplatin + Paclitaxel in Platinum Resistant Ovarian Cancer Cells

Issue: 
DOI: 
10.7727/wimj.2015.045
Pages: 
668–73
Synopsis: 
The cytotoxic efficacy of Vitamin E and the focal adhesion kinase inhibitor Y15 was evaluated for their ability to enhance sensitivity to cisplatin and paclitaxel in a platinum resistant ovarian cancer cell line.

ABSTRACT

Accepted: 
23 Mar, 2015
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e-Published: 16 Oct, 2015

Monoclonal Antibodies in Cancer Therapy: Mechanisms, Successes and Limitations

Issue: 
DOI: 
10.7727/wimj.2013.241
Pages: 
650–4
Synopsis: 
The classification, efficacy and significantly reduced toxicity of chemotherapeutic monoclonal antibodies (CmAbs) available for use in the United States of America are presented, and their limitations and future considerations are explored.

ABSTRACT

Accepted: 
24 Feb, 2014
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e-Published: 29 May, 2014

Evaluation of the Hypoglycaemic Activity of Petiveria alliacea (Guinea Hen Weed) Extracts in Normoglycaemic and Diabetic Rat Models

Issue: 
DOI: 
10.7727/wimj.2013.142
Synopsis: 
The aqueous and hexane extracts of Petiveria alliacea were investigated for hypoglycaemic properties in normoglycaemic and streptozotocin-induced diabetic rats. The findings demonstrated no significant changes in blood glucose levels in response to Petiveria alliacea treatment.

ABSTRACT

Objective: Petiveria alliacea (P alliacea) has ethno-traditional use as a hypoglycaemic agent in Jamaica and is yet to be scientifically validated as such.  Therefore, extracts of aerial parts of the plant were evaluated for hypoglycaemic activity in normoglycaemic and diabetic rats.

Revised: 
20 Sep, 2013
Accepted: 
27 Sep, 2013
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e-Published: 18 Feb, 2014

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

Anti-inflammatory Activities of Cassia alata Leaf Extract in Complete Freund’s Adjuvant Arthritis in Rats

Issue: 
Pages: 
615–21
Synopsis: 
The anti-inflammatory effects of Cassia alata leaf extract were investigated on complete Freund’s adjuvant induced arthritic rats. The extract from the leaves was able to significantly reduce the swelling observed in the knee joint. It was also able to effectively protect the articular cartilage from degradation as well as limit the number of differential leukocytes entering the synovial cavity during inflammation. Cassia alata possesses potent anti-inflammatory effects and should undergo further investigations of these properties.
 
ABSTRACT
 
Objective: To investigate the anti-inflammatory effects of a hexane extract of Cassia alata leaves in complete Freund’s adjuvant (CFA) arthritis in rats.
 
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e-Published: 03 Feb, 2014

Cassia alata Leaf Extract Induces Cytotoxicity in A549 Lung Cancer Cells via a Mechanism that is Caspase 8 Dependent

Issue: 
Pages: 
608–14
Synopsis: 
The cytotoxic effect of a hexane extract of Cassia alata (C alata) leaves in parental and Caspase 8, 3 and 9 negative A549 lung cancer cells was evaluated after a 24-hour treatment period. C alata extract was cytotoxic in parental and caspase-9 negative, but not caspase 3 and 8 negative A549 cells. The IC50 values were 143 μg/ml and 145 μg/ml in parental and caspase 9 negative A549 cells respectively. The flavanoid kaempferol was identified as a constituent of C alata leaf extract. These results suggest a cytotoxic effect of C alata that is dependent on caspase 8.
 
 
ABSTRACT
 
Objective: To evaluate the cytotoxic effect of a hexane extract of Cassia alata leaves in A549 lung cancer cells.
 
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e-Published: 03 Feb, 2014
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