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Protective Effects of Liquiritin on the Brain of Rats with Alzheimer’s Disease

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Background: Alzheimer’s disease (AD) is a sort of nerve degenerative disease with clinical manifestation of memory damage and cognitive dysfunction. Its typical pathological change is the abnormal deposition of amyloid-beta (Aβ).  

Method: In this study, a rat AD model with liquiritin (LQ) interference was established to observe the effects of LQ on the AD rats’ behavioural memory and primary hippocampus cells.  

Results: Liquiritin had the effect of improving the rats’ learning and memory ability, enhancing the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in rats’ brain tissues, increasing the antioxidant ability, protecting the primary cultured hippocampal neurons and inhibiting the apoptosis induced by Aβ25–35.  

Conclusion: The protective effects of LQ can be related to the enhancement of antioxidase activity and clearance of oxygen radicals.  

08 Feb, 2016
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e-Published: 18 Apr, 2016
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