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Serum Magnesium and High Sensitive C-Reactive Protein in Hypertensive Obese Female School Learners



Objective: To examined the relationship of serum magnesium and high sensitive C-reactive proteins (hsCRP) with overweight/obesity and its association with hypertension in lean versus overweight/obese female adolescent school learners living in Mthatha, South Africa.

Methods: A case-control study was conducted involving age-matched, non-pregnant and non-lactating lean and overweight/obese females aged 13 – 17 years. Relevant data on demography, anthropometry (height, weight, waist and hip circumferences), blood pressure and venous blood samples were collected.

Results: A significant inverse correlation was observed between serum magnesium and waist circumference (r=-0.3153, 95% CI = -3.843 to –0.8681, p = 0.0022). Serum hsCRP levels were significantly higher in overweight/obese participants. Participants with waist circumference (WC) > 80 cm had significantly higher mean systolic blood pressure and mean diastole blood pressure (MDBP). Hip circumference (HC) >94 cm was associated with higher mean systole blood pressure (MSBP) and MDBP (120±2 vs 113±2, p=0.009 and 73±2 vs 68±1, p=0.003). Both WC and hip circumference correlated positively with both MSBP (r=0.2691, 95% CI = 0.042 – 0.457, p = 0.018; r=0.2758, 95% CI = 0.03184 – 0.3001, p = 0.0159) and MDBP (r=0.2686, 95%CI = 0.0286 – 0.320, p=019; r=0.2836, 95% CI = 0.05382 – 0.4455, p = 0.013), respectively.

Conclusion: Findings of low grade inflammation and early onset-hypertension in overweight/obese adolescent females in our study were consistent with evidences supporting the beneficial effect of maintaining lean body habitus. There is urgent need to prevent overweight/obesity among adolescents. 

12 Jun, 2015
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e-Published: 05 May, 2016

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