Close Menu

Books in a Library

The Relation of Polysomnographic Parameters to Carotid and Brachial Artery Intima-media Thickness in Patients with Severe Obstructive Sleep Apnea Syndrome



Objective: To evaluate carotid (C) and brachial (BA) artery intima-media thickness (IMT) in patients with severe obstructive sleep apnea syndrome (OSAS) along with factors predicting CIMT and BA-IMT increase.

Method: A total of 81 patients with severe OSAS (Mean (SD) age: 48.0(10.5) years, 70.4% were males) and 49 healthy controls (Mean (SD) age: 47.9(9.7) years, 73.5% were males) were included. Data on demographics, cardiovascular risk factors and CIMT and BIMT values were evaluated in each subject along with factors predicting CIMT and BIMT increase in the patient group.

Result: Mean (SD) left and right CIMT and BIMT were significantly higher in OSAS than control group (p<0.001 for each). There was no significant association of polysomnographic parameters with CIMT. Average apnea duration was associated with increase in right and left BA-IMT (B=0.011, p=0.011 for the right and B=0.011, p=0.002 for the left). A significant negative association was noted between average oxygen saturation and left BA-IMT (B=-0.012, p=0.005).

Conclusion: Our findings revealed significant increase in of CIMT and BA-IMT in patients with severe OSAS compared to controls. None of the polysomnographic parameters, but age and smoking, was determinants of increased CIMT, while apnea duration and arousal index were significant predictors of BA-IMT. 

15 Jun, 2016
PDF Attachment: 
e-Published: 21 Jul, 2016


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Top of Page