Objective: This study aims to determine the expression and significance of Triple Wide Straight Grooves 1 (TWSG1) in craniofacial fibrous dysplasia (FD).
Methods: TWSG1 expression was examined in specimens obtained from 44 patients with FD by immunohistochemistry.
Results: TWSG1 expression was positive in all FD patients, which was higher than in patients with normal mandible in the negative control group (P<0.05). Furthermore, the positive rate of TWSG1 was slightly higher than in adult patients with FD (P<0.05), which was classified by post-operativerecurrence or no recurrence. Moreover, the positive expression of TWSG1 in FD with favorable prognosis was higher than that with poor prognosis (P<0.05).
Conclusion: The overexpression of TWSG1 is a vital biological marker in the prognosis of FD.
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