ABSTRACT
Objectives: The objective of this study was to assess anti-inflammatory, anti-pyretic and anti-nociceptive activities of methanol extract of Tamarix Aphylla (TAME) in experimental animal models.
Methods: The TAME was evaluated via carrageenan induced edema and xylene induced ear edema models for anti-inflammatory, brewer yeast induced pyrexia model for anti-pyretic activity, hot plate and acetic acid induced writhing models for anti-nociceptive properties.
Results: The outcomes indicated that TAME in inflammatory models at a dose level of 100 and 200 mg/ kg exhibited statistically significant anti-inflammatory activity 51.84 %/ 68.59 % and 36.00 % / 61.17 % respectively. Similarly, TAME exhibited the maximum antipyretic effect at a dose level of 100 and 200 mg/ kg, which was 2.08 % and 2.72 % respectively. Moreover, the TAME demonstrated maximum percent inhibitory activity with a dose of 400 mg/kg in writhing and hot plate tests which was 50.40 % and 46.56 % respectively.
Conclusion: In conclusion, this study provides a pharmacological basis for the ethnopharmacological use of Tamarix aphylla as anti-inflammatory, anti-pyretic and analgesic herbal remedy.
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