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anti-inflammatory

Pharmacological Evaluation of Marginally Designed New Profen Analogues

DOI: 
10.7727/wimj.2016.400
Synopsis: 
This study was conducted for the pharmacological evaluation of some novel analogues of naproxen, flurbiprofen and ibuprofen, well established COX inhibitors, with the goal of identifying a COX inhibitor(s) with optimized potency and efficacy. The synthesized and characterized analogues were tested for their acute toxicity, anti-inflammatory, analgesic and antipyretic activities based on the reported bioassay models. Molecular docking analysis was also performed to predict ligand: protein interactions. The synthesized analogues have highly significant pharmacological activities and have the potential to be further explored as new drug molecules. 

ABSTRACT

Accepted: 
13 Feb, 2017
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Journal Sections: 
e-Published: 02 Mar, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Pharmacological Evaluation of Tamarix aphylla for Anti-inflammatory, Anti-pyretic and Anti-nociceptive Activities in Standard Animal Models

DOI: 
10.7727/wimj.2016.346
Synopsis: 
The present study provides pharmacological base for the medicinal use of Tamarix aphylla as anti-inflammatory, anti-pyretic and antinociceptive herbal remidies in standard animal models such as carrageenan induced edema and xylene induced ear edema models for anti-inflammatory, brewer yeast induced pyrexia model for anti-pyretic activity, hot plate and acetic acid induced writhing models for anti-nociceptive properties.

ABSTRACT

Objectives: The objective of this study was to assess anti-inflammatory, anti-pyretic and anti-nociceptive activities of methanol extract of Tamarix Aphylla (TAME) in experimental animal models.

Revised: 
09 Jan, 2017
Accepted: 
13 Jan, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 03 Feb, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Anti-inflammatory Activities of Cassia alata Leaf Extract in Complete Freund’s Adjuvant Arthritis in Rats

Issue: 
Pages: 
615–21
Synopsis: 
The anti-inflammatory effects of Cassia alata leaf extract were investigated on complete Freund’s adjuvant induced arthritic rats. The extract from the leaves was able to significantly reduce the swelling observed in the knee joint. It was also able to effectively protect the articular cartilage from degradation as well as limit the number of differential leukocytes entering the synovial cavity during inflammation. Cassia alata possesses potent anti-inflammatory effects and should undergo further investigations of these properties.
 
ABSTRACT
 
Objective: To investigate the anti-inflammatory effects of a hexane extract of Cassia alata leaves in complete Freund’s adjuvant (CFA) arthritis in rats.
 
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Journal Authors: 
e-Published: 03 Feb, 2014
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