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Fine-needle-aspiration (FNA) Cytology for SRC Type Breast Cancer: 13 Case Reports

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Objective: To investigate the cytohistological findings of 13 breast carcinoma cases with SRCs

Methods: From January 2006 to August 2015, 13 cases of SRC type breast cancer had undergone FNA cytology examination before excisional biopsy or operation. All the histological sections of each case were confirmed to have at least 20% SRCs in the tumor cells. The clini­copathological features of SRC type breast cancer were investigated.

Results: Of the 13 breast carcinoma cases, there were invasive ductal carcinoma (IDC) (n=5), invasive lobular carcinoma (ILC) (n=5), pleomorphic lobular carcinoma (PLC) (n=1), and mucinous carcinoma (MC) (n=2). 3 cases of IDC, 1 cases of PLC, and 1 case of MC had grade 2 or 3 nuclear atypia, whereas 1 case of IDC, 4 cases of ILC, and 1 case of MC had grade 1 nuclear atypia. Axillary lymph nodes were positive for metastatic carcinoma in 1 case with IDC and 1 case with ILC. In fine needle aspiration smears, the intracytoplasmic lumen (ICL) type SRCs were found to be major constituents of SRCs in ILC and PLC, while non-ICL type SRCs were predominant in IDC. MC tumors had SRCs of both ICL and non- ICL types. During our follow-up period ranging from 97 to 3650 (1458 ± 1055) days, all the patients were alive without recurrence of the tumor.

Conclusion: Our results indicate that the nature of SRCs may vary with the histological subtype of breast cancer, but its presence may not indicate poor prognosis. 

30 Mar, 2017
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e-Published: 02 May, 2017


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