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Investigation of Metabolic Syndrome, Lipid Profile, and Levels of Apolipoprotein A-1, Apolipoprotein B100 and Small Dense LDL in Patients with Lichen Planus

DOI: 
10.7727/wimj.2017.134

ABSTRACT

Objective: Lichen Planus (LP) is an idiopathic inflammatory dermatosis involving skin, mucosa, hair follicles, and nails. Increased insulin resistance (IR) and dyslipidemia can be seen in LP. In this study, we aimed to investigate the relationship between LP and metabolic syndrome, atherogenicity, and dyslipidemia.

Methods: We enrolled 50 patients who were clinically and histopathologically diagnosed with LP and 30 healthy individuals whose body mass index (BMI), age, and sex were consistent with the LP group. Levels of Apo B100, small dense LDL and Apo AI, fasting serum insulin, C-peptide, glucose, total cholesterol, low dense lipoprotein (LDL), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL) were measured in all subjects. Metabolic syndrome parameters including anthropometric measures, lipid profiles, blood sugar and blood pressure were investigated as well.

Results: The indicators of IR including HOMA-IR and C-peptide values were remarkably elevated in the LP group than the control group (p < 0.05). There was no statistically significant difference in the incidence of metabolic syndrome between the groups. There were no differences in the levels total cholesterol, triglyceride, LDL, serum Apo B-100, and small dense LDL between the groups (p = 0. 871, p =0. 941 respectively).  The level of Apo AI, anti-atherogenic molecule, was statistically elevated in LP patients than the control group (p = 0.015).

Conclusion: The increased risk of atherogenicity was not detected in the patients with LP. Increased IR was detected in the LP group. Further studies with larges sample sizes are warranted to investigate the relationship between LP and hyperlipidemia. 

Accepted: 
15 Dec, 2017
Weight: 
0
e-Published: 19 Dec, 2017

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