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insulin resistance

Practical Predictors of Fibrosis in Non-alcoholic Fatty Liver Disease: Immunoglobulin-A and HOMA-IR

DOI: 
10.7727/wimj.2018.013
Synopsis: 
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease and advanced fibrosis is the most important predictor of mortality in NAFLD. In this study, homeostasis model of insulin resistance (HOMA-IR) and serum immunoglobulin (Ig) A levels are found as the independent predictors of hepatic fibrosis. Early estimation of fibrosis in NAFLD patients by using clinical parameters such as HOMA-IR and serum IgA that can be easily assessed during daily routine can lead to a strategy to choose the most appropriate candidate for liver biopsy and can increase the yield and decrease unnecessary biopsies with associated costs and morbidity.

ABSTRACT

Objective: Elevated immunoglobulin (Ig)-A levels and its relationship with fibrosis in alcoholic liver disease (ALD) were known. Non-alcoholic fatty liver disease (NAFLD) shows similar histology and pathophysiology with ALD. The potential relationship of serum Ig (IgA, IgG, and IgM) levels and other routinely used biochemical tests with the histological stage of liver damage in biopsy-proven NAFLD patients was investigated here.

Accepted: 
08 Aug, 2018
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Journal Sections: 
e-Published: 14 Feb, 2019

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Investigation of Metabolic Syndrome, Lipid Profile, and Levels of Apolipoprotein A-1, Apolipoprotein B100 and Small Dense LDL in Patients with Lichen Planus

DOI: 
10.7727/wimj.2017.134
Synopsis: 
This study evaluated the incidence of metabolic syndrome and lipid profile in patients with lichen planus. The indicators of IR including HOMA-IR and C-peptide values were remarkably elevated in the LP group and there were no differences in the levels total cholesterol, triglyceride, LDL, serum Apo B-100, and small dense LDL between the groups.

ABSTRACT

Objective: Lichen Planus (LP) is an idiopathic inflammatory dermatosis involving skin, mucosa, hair follicles, and nails. Increased insulin resistance (IR) and dyslipidemia can be seen in LP. In this study, we aimed to investigate the relationship between LP and metabolic syndrome, atherogenicity, and dyslipidemia.

Accepted: 
15 Dec, 2017
Journal Sections: 
e-Published: 19 Dec, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Correlation Study of Insulin Resistance and Adipocytes Factors in Patients with Type 2 Diabetes

DOI: 
10.7727/wimj.2014.382
Synopsis: 
The aim of this study was to investigate the insulin resistance and adipocytes factors in patients with Type 2 diabetes. The results of stepwise regression analysis showed that resistin, TNF-α and FFA were significantly associated with insulin resistance index (IRI).

ABSTRACT

Objective: 30 cases of non-obese patients with type 2 diabetes, 30 cases of obese patients with type 2 diabetes and 30 cases of healthy controls were selected to detect the levels of serum resistin, TNF-α, FFA, fasting blood glucose, fasting insulin, total cholesterol and triglycerides.

Accepted: 
23 Mar, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 15 Jun, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Which Factors are Predictive for the Presence of Insulin Resistance in Patients with Rheumatoid Arthritis?

DOI: 
10: 107727/wimj.2015.463
Synopsis: 
We investigated obesity and insulin resistance and associated factors in patients with rheumatoid arthritis. Cumulative steroid dose, the presence of obesity and disease activity, were the best predictors for insulin resistance. Disease modifying antirheumatic drugs may help to reduce insulin resistance.

ABSTRACT

Aims: The aim of this study was to investigate of obesity and insulin resistance and associated factors in patients with rheumatoid arthritis (RA).

Accepted: 
25 Nov, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 17 Feb, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Assessment of the Ability of the Triglyceride to High Density Lipoprotein Cholesterol Ratio to Discriminate Insulin Resistance among Caribbean-born Black Persons with and without Hispanic Ethnicity

Issue: 
DOI: 
10.7727/wimj.2012.186
Pages: 
109–13
Synopsis: 
Identifying persons who are insulin resistant is important for preventing Type 2 diabetes and cardiovascular disease. This study assesses the ability of the triglyceride to high density lipoprotein cholesterol ratio to identify Caribbean-born Hispanic black and non-Hispanic black persons with insulin resistance.

ABSTRACT

Objective: The objective of this research was to determine if the triglyceride (TG) to high density lipoprotein (HDL) cholesterol (TG/HDL) ratio has similar utility for discriminating insulin resistance in Caribbean-born black persons with and without Hispanic ethnicity.

Accepted: 
02 Aug, 2012
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 16 May, 2013

Insulin Control of Blood Glucose and GLUT4 Expression in the Skeletal Muscle of Septic Rats

Issue: 
DOI: 
10.7727/wimj.2013.181
Pages: 
62–70
Synopsis: 
Insulin increased the expression of GLUT4 mRNA and GLUT4 in the skeletal muscle of septic rats. Blood glucose concentration of 8–10 mmol/L results in more glucose utilization than 6–8 mmol/L in the skeletal muscle of septic rats during insulin therapy.

ABSTRACT

Background: Insulin resistance is common in septic patients. The level at which the serum glucose should be maintained using insulin infusions for optimal utilization by skeletal muscles is not yet established.

Accepted: 
03 Jul, 2013
PDF Attachment: 
Journal Sections: 
e-Published: 16 Dec, 2014
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