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Randomized Controlled Trial between Conventional Fractionation Radiotherapy and Accelerated Hyperfractionation Radiotherapy in the Elderly with Locally Advanced Non-small Cell Lung Carcinoma



Objective: This study aimed at observing and discussing the curative effect of conventional fractionation radiotherapy and accelerated hyperfractionation radiotherapy in the elderly
with locally advanced non-small cell lung carcinoma (NSCLC).

Methods: The study group consisted of 72 patients with locally advanced NSCLC (partly IIIA or IIIB stage) who were admitted between January 2009 and December 2010. They were divided randomly into two groups: 36 in the observation group and 36 in the control group. The
control group was treated by conventional fractionation radiotherapy, while the observation group received accelerated hyperfractionation radiotherapy. After three months, six months and one year, at follow-up visits, the comprehensive curative effect was evaluated, and the data
on disease-free survival and radiation toxic reaction were acquired. Sixty-four samples were included in this research after excluding patients with distant metastasis and other internal medicine diseases.

Results: The remission rate (complete remission + partial remission) in the observation group was 75.0% (24/32) while that in the control group was 62.5% (20/32). The remission rate in the observation group was significantly higher than that in the control group (p < 0.05). The
progression-free survival (PFS) in the observation group at three months, six months and one year was 81.3% (26/32), 31.2% (10/32) and 18.7% (6/32), respectively. The corresponding data in the control group was 6.2% (18/32), 28.1% (9/32) and 15.6% (5/32), respectively. The
three-month PFS in the observation group was significantly higher than that in the control group (p < 0.05). There was no statistically significant difference in myelosuppression, radiation oesophagitis and radiation pneumonitis (p > 0.05).

Conclusion: Compared with conventional fractionation radiotherapy in treating locally advanced NSCLC, accelerated hyperfractionation radiotherapy showed better short-term
decentralized control effect. The toxic effects were similar in the two therapies.

22 Aug, 2016
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e-Published: 09 Jul, 2018
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