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Patterns of Azole Susceptibility of Candida albicans Isolated from Clinical Samples at a Tertiary Care Hospital in Georgetown, Guyana



Objective: This study sought to examine the frequency of isolation and azole susceptibility patterns of clinical Candida albicans isolates from a tertiary hospital in Georgetown, Guyana during a three-month period.

Methods: Isolation and germ-tube identification of Candida sp were done by the hospital Microbiology Department. Further identification was made by assessing the colour and morphology of Candida isolates subcultured from SDA onto HardyCHROM Candida. Antifungal susceptibility testing and results interpretation were performed in accordance with the CLSI M44-A2 guidelines.

Results: sixty-two non-duplicate isolates of Candida were analysed from multiple patient sources. The majority of these isolates were Candida albicans (56.5%), while the remainder (43.5%%) were non-C albicans species of which C glabrata (32.3%) and C krusei (8.1%) were the predominant species. 28.6% of the C albicans isolates were resistant to fluconazole and voriconazole, respectively, while 40% of the isolates were resistant to itraconazole.

Conclusion: Azole resistance is a common phenomenon among C albicans isolates within the setting of the Georgetown Public Hospital Corp (GPHC).


22 May, 2018
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e-Published: 26 Feb, 2019


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