Laparoscopic pancreaticoduodenectomy (LPD) was still one of the most challenging endoscopic surgeries by far and there were still some technical problems to be resolved. In this study, we try to investigate the difficulties and countermeasures of the LPD using a retrospective analysis for the surgical techniques of the LPD carried out for 40 patients in our hospital from December 2009 to Jul 2015 and the clinical data such as operative time, intra-operative blood loss, numbers of scavenged lymph node and postoperative complications were collected. The result showed that application of appropriate surgical approach, improvement of the resection of UP and modification of the pancreaticojejunostomy(PJ) could make the LPD easier and safer.