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transient receptor potential channels

The Effects of Lung Ischaemia/Reperfusion on TRPM Gene Expression

The study investigated the contribution of these genes in lung ischemia/reperfusion injury and evaluate histopathology of tissues. The major histopathological tissue damage was observed in ischemia performed groups and expression of transient receptor potential melastatin (TRPM) channels was found to be obviously down-regulated. The results indicate that TRPM family of cation channels may have significant roles in the lung ischemia/reperfusion injury.


Objective: Transient receptor potential melastatin (TRPM) are integral membrane proteins that have broad range of cellular functions. Roles of TRPM2, TRPM3, TRPM4 and TRPM7 among these channels are very important, and their roles in lung ischaemia/reperfusion injury have not been evaluated yet. The aim of this study is to investigate the contribution of these genes in lung ischaemia/reperfusion injury and evaluate histopathology of tissues.

01 Sep, 2016
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e-Published: 02 Sep, 2016
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