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Late Onset Systemic Lupus Erythematosus with Severe Hypercalcaemia

Journal Authors: 
Issue: 
DOI: 
10.7727/wimj.2012.013
Pages: 
92–4

ABSTRACT

We report a case of a 76-year old female presenting with symptomatic severe hypercalcaemia, and subsequently diagnosed with late onset SLE due to the presence of anaemia, leucopenia, antibodies of antinuclear (ANA), anti-dsDNA, and also kidney impairment. Serum levels of FGF23 and intact-parathyroid hormone (iPTH) were low in this patient. Serum calcium, FGF23 and iPTH levels responded to steroids, which occurred simultaneously with disease activity. On follow-up, the faster increase in FGF23 than in parathyroid hormone suggested that FGF23 might be involved in the pathogenesis of hypercalcaemia in SLE.

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e-Published: 14 Mar, 2013
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