J Liu

Knockdown of ET-1 Gene Can Inhibit the Proliferation, Invasion of Human Prostate Cancer Cell

DOI:

10.7727/wimj.2016.456

Synopsis:

Synopsis: This study estimated the effects of knockdown the gene Endothelin-1(ET-1) to human prostate cancer cell. The results of this study can describe the characterization of ET-1in the development of primary human Prostate cancer, which can lead to a better understanding of the changes occurring at the molecular level during the development and progression of cancer.

ABSTRACT

Received:

23 Aug, 2016

Accepted:

13 Feb, 2017

PDF Attachment:

liu_and_liu-et-1_gene_effects_on_prostate_cancer_cell.pdf

Journal Sections:

Keywords:

prostate cancer; western blot

Journal Authors:

J Liu

X Liu

e-Published: 03 Mar, 2017

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Mass Spectrometric Analysis of Cerebrospinal Fluid Protein for Glioma and its Clinical Applications

DOI:

10.7727/wimj.2015.233

Synopsis:

The combination of SELDI-TOF-MS and bioinformatics tools is a very effective method for screening and identifying new marker of glioma. The established diagnosis models have provided a new way for the clinical diagnosis of glioma, especially for qualitative diagnosis.

ABSTRACT

Objective: To establish and evaluate the fingerprint diagnostic models of cerebrospinal protein profile in glioma Using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) and bioinformatics analysis, for seeking new tumor markers.

Received:

06 May, 2015

Accepted:

18 May, 2015

PDF Attachment:

liu20et20al-mass20spectrometric20analysis20for20glioma1.pdf

Journal Sections:

Original Articles

Keywords:

Artificial neural network

support vector machine

Journal Authors:

e-Published: 10 Nov, 2015

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Survival of Cochlear Spiral Ganglion Neurons Improved in vitro by Anti-miR204 via TMPRSS3

Issue:

Vol 65, Issue 2: 2016

DOI:

10.7727/wimj.2014.393

Pages:

379-82

Synopsis:

The survival of cochlear spiral ganglion neurons was increased in mice with kanamycin ototoxicity whose cochlea were micro-injected with AAV1-anti-miR204, which suggested that anti-miR204 could be a potential therapeutic strategy in sensorineural hearing loss.

ABSTRACT

Objective: Sensorineural hearing loss (SNHL) is caused by damage to hair cells followed by degeneration of the spiral ganglion neurons (SGNs) and cochlear implanting is an effective treatment. Unfortunately, the progressive hearing loss is still found due to ongoing degeneration of cochlear SGNs. The aim of this study was to investigate the neuroprotective effect of antimiR204 on SGNs in vivo.

Received:

04 Dec, 2014

Accepted:

05 Jan, 2015

PDF Attachment:

wimj_iss2_2016_379-82.pdf

Journal Sections:

Short Communication

Keywords:

MiR204

Kanamycin ototoxicity

sensorineural hearing loss

spiral ganglion neurons TMPRSS3

Journal Authors:

e-Published: 08 May, 2015

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Different Doses and Routes of Administration of Methimazole Affect Thyroid Status in Methimazole-induced Hypothyroidism in Rats

Issue:

Vol 65, Issue 1: 2016

DOI:

10.7727/wimj.2014.241

Pages:

93–7

Synopsis:

In the present study, we established and compared differences of the rat’s hypothyroid model induced by MMI added to drinking water or given through an intragastric tube.

ABSTRACT

Objective: It is agreed that methimazole (MMI) can be administered to induce hypothyroidism. However, there are conflicting data about its effect on thyroid function and development in rats through different administrations. In the present study, we established and compared differences of the rat hypothyroid model induced by MMI added to drinking water or given through an intragastric tube.

Received:

06 Oct, 2014

Accepted:

31 Oct, 2014

PDF Attachment:

wimj_iss1_2016_93_97.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 07 May, 2015

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Site-directed Mutagenesis (Y52E) of POLH Affect Its Ability to Bypass Ultraviolet-induced DNA Lesions in HaCaT Cells

Issue:

Vol 63, Issue 4: Aug (2014)

DOI:

10.7727/wimj.2014.063

Pages:

307–11

Synopsis:

Site-directed mutagenesis (Y52E) of POLH has reduced capacity to bypass ultraviolet-induced DNA lesions in HaCaT cells.

ABSTRACT

Received:

17 Mar, 2014

Accepted:

27 Mar, 2014

PDF Attachment:

luo_et_al-polh_mutation_in_hacat_cells.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 22 Apr, 2014

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The Application of Chromosome Abnormality Chip Detection in Male Infertility

Issue:

Vol 62, Issue 8: Nov (2013)

DOI:

10.7727/wimj.2013.213

Synopsis:

Chromosome abnormality chip detection system provides a sensitive, economic and high-throughput method for detecting the deletion or amplification of genomic DNA sequences of infertile patients.

ABSTRACT

Objective: To discuss the application of microarray technology in the diagnosis of male infertility.

Methods: Sixteen loci, including a sex-determining region on the Y chromosome, were investigated by polymerase chain reaction (PCR) in infertile male patients. Chromosome abnormality chip with 180 000 probes was used to detect small deletion, small amplification and loss of heterozygosity.

Received:

12 Aug, 2013

Accepted:

20 Aug, 2013

PDF Attachment:

dr_j_liu.qxd_.pdf

Journal Sections:

Original Articles

Keywords:

Infertility

polymerase chain reaction

Chip detection

chromosome abnormality

Journal Authors:

e-Published: 02 Apr, 2014

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Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.