Objective: To evaluate neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) in patients with gouty arthritis.
Methods: Forty-five patients with gout and 45 healthy age and gender-matched individuals, were included in this study. Clinical and laboratory data of patients during acute gouty arthritis (AGA) attack period, as well as in remission and control group data were reviewed and recorded from medical files. Patients were divided into two groups as having the arthritis attack and in remission.
Results: NLR values were 4.19±3.37 in AGA patients, 2.64±1.74 in patients in remission, and 2.07±1.01 in controls. NLR values in AGA were higher than patients in remission and controls, whereas there was no difference between patients in remission, and controls (p < 0.0001, p < 0.0001, p = 0.453; respectively). MLR values were 0.36 ± 0.21 in AGA patients, 0.25±0.15 in patients in remission, and 0.22 ± 0.06 in controls.MLR was higher in AGA patients than patients in remission, and controls, but there was no difference between patients in remission and healthy individuals (p < 0.0001, p < 0.0001, p = 0.604; respectively). NLR and MLR values in AGA patients had positive correlations with CRP, ESR and leukocyte count. The cut-off value of NLR was 2.18 in ROC analysis (73% sensitivity, 63% specificity, AUC 0.676; p = 0.004). The cut-off value of MLR was 0.22 in ROC analysis (62% sensitivity, 54% specificity, AUC 0.655; p = 0.011).
Conclusions: We concluded that MLR and NLR could be used as a cheap and useful inflammatory marker predicting arthritis attacks in patients with gout.
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