Close Menu

Evaluation of Neutrophil to Lymphocyte Ratio and Monocyte to Lymphocyte Ratio in Gouty Arthritis Attacks



Objective: To evaluate neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) in patients with gouty arthritis.

Methods: Forty-five patients with gout and 45 healthy age and gender-matched individuals, were included in this study. Clinical and laboratory data of patients during acute gouty arthritis (AGA) attack period, as well as in remission and control group data were reviewed and recorded from medical files. Patients were divided into two groups as having the arthritis attack and in remission.

Results: NLR values were 4.19±3.37 in AGA patients, 2.64±1.74 in patients in remission, and 2.07±1.01 in controls. NLR values in AGA were higher than patients in remission and controls, whereas there was no difference between patients in remission, and controls (p < 0.0001, p < 0.0001, p = 0.453; respectively). MLR values were 0.36 ± 0.21 in AGA patients, 0.25±0.15 in patients in remission, and 0.22 ± 0.06 in controls.MLR was higher in AGA patients than patients in remission, and controls, but there was no difference between patients in remission and healthy individuals (p < 0.0001, p < 0.0001, p = 0.604; respectively). NLR and MLR values in AGA patients had positive correlations with CRP, ESR and leukocyte count. The cut-off value of NLR was 2.18 in ROC analysis (73% sensitivity, 63% specificity, AUC 0.676; p = 0.004). The cut-off value of MLR was 0.22 in ROC analysis (62% sensitivity, 54% specificity, AUC 0.655; p = 0.011).

Conclusions: We concluded that MLR and NLR could be used as a cheap and useful inflammatory marker predicting arthritis attacks in patients with gout.

21 Aug, 2015
PDF Attachment: 
e-Published: 15 Oct, 2015


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Top of Page