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M Şahin

Evaluation of Neutrophil to Lymphocyte Ratio and Monocyte to Lymphocyte Ratio in Gouty Arthritis Attacks

DOI: 
10.7727/wimj.2015.345
Synopsis: 
Gout is an auto-inflammatory disease caused by accumulation of monosodium urate crystals in tissues and organs due to hyperuricemia. Neutrophils, lymphocytes, and monocytes play a role in acute gouty arthritis (AGA) pathogenesis, directly or indirectly, and/or via complex interaction between them. Ratios between these immune system elements have been listed in inflammatory markers which have been used more frequently recently. The present study is the first one to evaluate NLR and MLR in gout, and to investigate the correlation between these and AGA. We found that NLR and MLR were higher in AGA patients when compared with patients in remission and controls, and they had correlations with other inflammatory markers, which suggested a possible correlation with AGA. In conclusion, NLR and MLR values could be used as a cheap and useful inflammatory marker to predict arthritis attacks in patients with gout.

ABSTRACT

Objective: To evaluate neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) in patients with gouty arthritis.

Accepted: 
21 Aug, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 15 Oct, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Can Mean Platelet Volume Be a Surrogate Marker of Inflammation in Rheumatic Diseases?

Issue: 
DOI: 
10.7727/wimj.2014.202
Pages: 
165–9
Synopsis: 
It has been suggested that low-level mean platelet volume (MPV) in humans may be related to secondary thrombosis due to inflammation. For this reason, MPV can be used as a marker showing inflammation in the body. In this study, we found a strong association between MPV and erythrocyte sedimentation rate and C-reactive protein in patients with rheumatic diseases. Thus, MPV may be used as a negative acute-phase reactant in rheumatic diseases.

ABSTRACT

Background: In humans, it has been suggested that low-level mean platelet volume (MPV) may be related to secondary thrombosis due to inflammation. For this reason, MPV can be used as a marker showing inflammation in the body. 

Accepted: 
23 Oct, 2014
PDF Attachment: 
Journal Sections: 
e-Published: 06 May, 2015
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