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Circulating Adipokine Levels in Non-diabetic Subjects with High Normal Blood Pressure



Objective: This study aimed to evaluate the levels of the adipokines, resistin and adiponectin in normotensive and high normal blood pressure patients.

Methods: Circulating levels of the adipokines, resistin and adiponectin, were measured by enzyme-linked immunosorbent assay (ELISA) [RyDSystems, Minneapolis, MN, USA] in 20 high normal blood pressure patients and in 20 age-matched normotensive non-diabetic subjects.  Statistical analysis was performed with analysis of variance (ANOVA).

Results: We found that the control group showed non-significantly decreased levels of resistin when compared with patients with high normal blood pressure patients [systolic 130–139 mmHg; diastolic 80–90 mmHg] (12.25 vs 14.38 pg/mL, p = 0.40). There were significantly higher levels of adiponectin in the control group when compared with high normal blood pressure patients (11.3 vs 7.51 μg/mL, p = 0.028).

Conclusion: High normal blood pressure patients have increased levels of resistin and lower values of adiponectin when compared with age-matched non-diabetic normotensive subjects. This may explain why those patients showed more progression to hypertension, atherosclerosis and cardiovascular risk than normotensive subjects.

25 Mar, 2015
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e-Published: 23 Nov, 2015
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