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Investigation of Paraoxanase Enzyme Polymorphism in Patients with Alopecia Areata

DOI: 
10.7727/wimj.2015.491

ABSTRACT

Objective: In this study, we investigated the relationship between AA and genetic polymorphisms of PON1 R192Q and PON1 L55M.

Methods: One hundred and nineteen patients with AA and 104 healthy controls were included in this study. The changes in aminoacid squencies on codon 55 and 192 were analysed by the polymerase chain reaction and restriction enzymes.

Results: The frequencies of M, L homozygotes and ML heterozygotes on PON 55 region were 11.8%, 58% and 30.2%, respectively in the patient group while they were 12.5%, 43.3% and 44.2%, respectively in the control group. The frequencies of R, Q homozygotes and RQ heterozygotes  on PON1 192 region were 10.9%, 41.2% and 47.9%, respectively in the patient group while they were  9.6%, 42.3% and 48.1%, respectively in the control group. While the frequency of PON 55 L allele was higher in patient group than control group, there were no differences in the frequency of 192 R allel between the groups (p = 0.07, p = 0.947, respectively).

Conclusions: There were no statistically significant  relations between the  AA and the PON1 ML55 and QR192 polymorphism. Although the frequency of PON 55 L allel was higher in the patient group than control group, there were no relation between the AA  and both PON1 M/L55 and R/Q192 polymorphism.

Accepted: 
30 Sep, 2015
PDF Attachment: 
e-Published: 15 Mar, 2016

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