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polymorphism

Association between Mannose-Binding Lectin 2 Gene Polymorphism and Liver Fibrosis in Patients with Chronic Viral Hepatitis

DOI: 
10.7727/wimj.2016.155
Synopsis: 
MBL2 Gene Polymorphism were investigated in patients with viral Hepatitis B and C. No significant differences in allele frequencies for any polymorphism were observed between patients and controls.

ABSTRACT

Objective: Mannose-Binding Lectin (MBL) has become a popular molecule in investigations on basic and clinical Gastroenterology and contributed to new approaches to the understanding of infectious and immune diseases associated with intestine and liver. The aim of the present study was to investigate the association between codon 54 polymorphisms in MBL2 gene coding MBL and predisposition to fibrosis in patients with viral Hepatitis B and C.

Accepted: 
25 May, 2016
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e-Published: 14 Jul, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Investigation of Paraoxanase Enzyme Polymorphism in Patients with Alopecia Areata

DOI: 
10.7727/wimj.2015.491
Synopsis: 
We investigated the relationship between alopecia areata (AA) and polymorphisms of paraoxanase 1 (PON1). Although the frequency of PON 55 L allel was higher in the patient group than control, there was no relation between the AA and both PON1 M/L55 and R/Q192 polymorphism.

ABSTRACT

Objective: In this study, we investigated the relationship between AA and genetic polymorphisms of PON1 R192Q and PON1 L55M.

Methods: One hundred and nineteen patients with AA and 104 healthy controls were included in this study. The changes in aminoacid squencies on codon 55 and 192 were analysed by the polymerase chain reaction and restriction enzymes.

Accepted: 
30 Sep, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 15 Mar, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Glutathione S-Transferase M1 and T1 Gene Polymorphisms Are Not Associated with Increased Risk of Gestational Diabetes Mellitus Development

Issue: 
DOI: 
10.7727/wimj.2013.128
Pages: 
300–6
Synopsis: 
Glutathione s-transferase M1 and T1 gene polymorphisms were investigated. They could not be indicated as a predisposing factor for the development of gestational diabetes mellitus

ABSTRACT

Aim: The aim of this study was to investigate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) gene polymorphisms contributed to development of gestational diabetes mellitus (GDM).

Accepted: 
27 Aug, 2013
PDF Attachment: 
Journal Sections: 
e-Published: 15 May, 2014

Investigation of CTLA-4 and CD28 Gene Polymorphisms in Patients with Diabetes Mellitus Type 2 Using PCR-RFLP in a Turkish Population

Issue: 
Pages: 
235–40
Synopsis: 
The CTLA-4 gene c.49A >G and c.-319C >T, and CD28 gene c.534+17T >C polymorphisms did not represent an important risk factor for this disease in a Turkish population.

ABSTRACT

Objective: The aim of this study is to investigate whether specific polymorphisms in the CTLA-4 and CD28 gene are associated with Type 2 diabetes mellitus (T2DM).

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e-Published: 07 Oct, 2013
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