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M Kulaç

Investigation of Paraoxanase Enzyme Polymorphism in Patients with Alopecia Areata

We investigated the relationship between alopecia areata (AA) and polymorphisms of paraoxanase 1 (PON1). Although the frequency of PON 55 L allel was higher in the patient group than control, there was no relation between the AA and both PON1 M/L55 and R/Q192 polymorphism.


Objective: In this study, we investigated the relationship between AA and genetic polymorphisms of PON1 R192Q and PON1 L55M.

Methods: One hundred and nineteen patients with AA and 104 healthy controls were included in this study. The changes in aminoacid squencies on codon 55 and 192 were analysed by the polymerase chain reaction and restriction enzymes.

30 Sep, 2015
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e-Published: 15 Mar, 2016


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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