Long non-coding RNAs (lncRNAs), a new class of non-coding RNAs longer than 200 nucleotides, have been recognized to regulate a wide variety of physiological and pathological processes through diverse mechanisms. Presently, only a small number of lncRNAs have been characterized functionally, and most of them are shown to act as regulators at different levels of gene expression (1, 2). Studies have revealed that many lncRNAs are shown to regulate important cancer hallmarks, including initiation, growth, and metastasis (3). However, whether lncRNA plays a role in cancer related inflammation is not clear yet. Recently, in Cancer Cell, Liu et al. reported a novel lncRNA upregulated by NF-κB (nuclear factor kappaB) was involved in cancer related inflammation by preventing over-activation of NF-κB pathway (4).
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