ABSTRACT
Objective: The study aimed to explore the correlation between urine interleukin (IL)-8, 6, 10, 17 levels and the efficacy of steroid in patients with idiopathic nephrotic syndrome (INS).
Methods: Forty-two INS patients were divided into steroid-sensitive (SS, n = 15) and steroid-resistant (SR, n = 27) groups. One-year follow-up study was performed, in which urine and serum IL-8, 6, 10, 17 levels were detected after initial treatment, remission and relapse.
Results: Steroid-resistant patients showed higher urine and serum IL-8 level than SS patients after initial treatment, which declined during remission and enhanced after relapse; there were no differences in IL-6, 10, 17 levels between the two groups. Urine IL-6, 10, 17 levels in patients with podocytopathy were higher than that of patients with other pathological types, and SR patients with podocytopathy had higher urine IL-8 level than those in SS group. Logister regression analysis showed that there was only IL-8 levels that was related to the effects of hormone therapy. The area under the curve of ROC for prediction of steroid efficacy with urine and serum IL-8 level were 0.871 (95% CI 0.63-0.921) and 0.633 (95% CI 0.431-0.805), respectively.
Conclusion: Urine IL-8 level can serve as an indicator for steroid efficacy in INS patients.
Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.
Our 7 faculties and 12 professional schools offer more than 200 programmes to some 18,000 graduate, undergraduate and continuing studies students.
The UWI, Mona ranks first in Jamaica among accredited tertiary-level programmes. In 2012, the University was again one of Jamaica’s Top 100 Employers.
