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Urine IL-8 is the Predictive Biomarker of Steroid Sensitivity in Patients with Idiopathic Nephrotic Syndrome



Objective: The study aimed to explore the correlation between urine interleukin (IL)-8, 6, 10, 17 levels and the efficacy of steroid in patients with idiopathic nephrotic syndrome (INS).

Methods: Forty-two INS patients were divided into steroid-sensitive (SS, n = 15) and steroid-resistant (SR, n = 27) groups. One-year follow-up study was performed, in which urine and serum IL-8, 6, 10, 17 levels were detected after initial treatment, remission and relapse.

Results: Steroid-resistant patients showed higher urine and serum IL-8 level than SS patients after initial treatment, which declined during remission and enhanced after relapse; there were no differences in IL-6, 10, 17 levels between the two groups. Urine IL-6, 10, 17 levels in patients with podocytopathy were higher than that of patients with other pathological types, and SR patients with podocytopathy had higher urine IL-8 level than those in SS group. Logister regression analysis showed that there was only IL-8 levels that was related to the effects of hormone therapy. The area under the curve of ROC for prediction of steroid efficacy with urine and serum IL-8 level were 0.871 (95% CI 0.63-0.921) and 0.633 (95% CI 0.431-0.805), respectively.

Conclusion: Urine IL-8 level can serve as an indicator for steroid efficacy in INS patients.

12 Dec, 2014
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e-Published: 10 Aug, 2016


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