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In-vivo Assessment of Antipyretic and Anti-inflammatory Activities of Gymnosporia royleana Extract in Mice

Issue: 
DOI: 
10.7727/wimj.2016.324
Pages: 
129–135

ABSTRACT

Objective: Despite the presence of multitude of synthetic drugs against fever and inflammation, none has been proven entirely safe. In contrast, the accepted safety of plant derived natural products is inspiring the world. Based on this fact as well as in view of the diversified activities reported from the genus Gymnosporia, the present study was designed to evaluate the antipyretic and anti-inflammatory activity of Gymnosporia royleana (G royleana).

Methods: The methanolic extract of the aerial parts of G royleana was screened for in-vivo antipyretic activity using the brewer’s yeast-induced pyrexia mice model and for anti-inflammatory activity using the carrageenan-induced paw oedema and xylene-induced ear oedema mice model.

Results: In the antipyretic assay, G royleana extract showed considerable antipyretic activity in a dose dependent fashion. Statistically significant antipyretic effects (p < 0.05) were observed at the end of the second hour of administration for all doses of extract and remained significant until the end of the experiment. The plant extract also displayed promising anti-inflammatory activity, in a dose dependent fashion, in both models of inflammation ie carrageenan- and xylene-induced oedema models, when compared to the controls. In the carrageenan-induced oedema model, significant effects (p < 0.01) were observed for 300 and 600 mg/kg doses after 60 minutes of xylene administration (ie 55.51% and 65.88% inhibition of oedema, respectively).

Conclusion: The study provided evidence supporting the antipyretic and antiinflammatory activity of the G royleana methanolic extract.

Accepted: 
03 Jan, 2017
Revised: 
19 Dec, 2016
PDF Attachment: 
Weight: 
-9
e-Published: 01 Feb, 2017
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