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Correlation Study of Insulin Resistance and Adipocytes Factors in Patients with Type 2 Diabetes

DOI: 
10.7727/wimj.2014.382

ABSTRACT

Objective: 30 cases of non-obese patients with type 2 diabetes, 30 cases of obese patients with type 2 diabetes and 30 cases of healthy controls were selected to detect the levels of serum resistin, TNF-α, FFA, fasting blood glucose, fasting insulin, total cholesterol and triglycerides.

Methods: And height, weight and waist circumference, abdominal circumference and blood pressure were measured, then body mass index (BMI) and waist-hip ratio (WHR) were calculated, as well as insulin resistance index (IRI) was calculated using Homa fomula.

Results: The results showed that the levels of resistin, TNF-α and FFA in the obese and non-obese diabetic groups were significantly higher than that in the control group, the difference was significant (p < 0.05, p < 0.01, respectively), the difference of resistin, the differences of TNF-α and FFA levels in the obese diabetic group were significant compared with that in the obese type 2 diabetic group (p < 0.05). The blood resistin in the non-obese type 2 diabetic groups had a significantly positive correlation with BMI, FPG and TG, as well as IRI, but no correlation with FINS, TCH, SBP, DBP and WHR.

Conclusions: The resistin, TNF-α and FFA in the non-obese type 2 diabetic group and control groups had no significant correlation with all factors. The results of stepwise regression analysis showed that resistin, TNF-α and FFA were significantly associated with IRI.

Accepted: 
23 Mar, 2015
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e-Published: 15 Jun, 2017

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