ABSTRACT
Objective: Thirty cases of non-obese patients with type 2 diabetes, 30 cases of obese patients with type 2 diabetes and 30 cases of healthy controls were selected to detect the levels of serum resistin, TNF-α, FFA, fasting blood glucose, fasting insulin, total cholesterol and triglycerides.
Methods: Height, weight and waist circumference, abdominal circumference and blood pressure were measured, then body mass index (BMI) and waist-hip ratio (WHR) were calculated, as well as insulin resistance index (IRI) was calculated using Homa fomula.
Results: The results showed that the levels of resistin, TNF-α and FFA in the obese and non-obese diabetic groups were significantly higher than that in the control group, the difference was significant (p < 0.05, p < 0.01, respectively), the difference of resistin, the differences of TNF-α and FFA levels in the obese diabetic group were significant compared with that in the obese type 2 diabetic group (p < 0.05). The blood resistin in the non-obese type 2 diabetic groups had a significantly positive correlation with BMI, FPG and TG, as well as IRI, but no correlation with FINS, TCH, SBP, DBP and WHR.
Conclusions: The resistin, TNF-α and FFA in the non-obese type 2 diabetic group and control groups had no significant correlation with all factors. The results of stepwise regression analysis showed that resistin, TNF-α and FFA were significantly associated with IRI.
Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.
Our 7 faculties and 12 professional schools offer more than 200 programmes to some 18,000 graduate, undergraduate and continuing studies students.
The UWI, Mona ranks first in Jamaica among accredited tertiary-level programmes. In 2012, the University was again one of Jamaica’s Top 100 Employers.
