Type 2 diabetes

Plasma Cellular Hypoxia, Mitochondrial Dysfunction, Disease Risk and Prognostic Factors in Type 2 Diabetic Patients in Saudi Arabia

Issue:

Vol 67, Issue 3: 2018

DOI:

10.7727/wimj.2017.117

Pages:

262-73

Synopsis:

This study investigated the level of plasma hypoxia-inducible factor (HIF)-1α and cytochrome c (CytoC) in correlation with C-reactive protein, dyslipidaemia, insulin resistance, and prognostic factors in Type 2 diabetic patients in Saudi Arabia. Reduced level of HIF-1α and non-significant increased level of CytoC correlated negatively with these prognostic factors. These results pointed to a possible pathogenetic implication for HIF-1α.

ABSTRACT

Objective: This cross-sectional study evaluated the association of plasma cytochrome c (CytoC) and hypoxia-inducible factor (HIF)-1α, as mitochondrial dysfunction and cellular hypoxia biomarkers, with disease risk factors and prognosis in Type 2 diabetic patients in Saudi Arabia.

Received:

09 Dec, 2016

Accepted:

30 Jun, 2017

Published:

19 Nov, 2018

PDF Attachment:

wimj-iss3-2018_262_273.pdf

Journal Sections:

Original Articles

Keywords:

C-reactive protein

cytochrome c

diabetic complications

hypoxia-inducible factor-1α

Type 2 diabetes

Journal Authors:

AA Alduraywish

e-Published: 21 Aug, 2017

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Correlation Study of Insulin Resistance and Adipocytes Factors in Patients with Type 2 Diabetes

DOI:

10.7727/wimj.2014.382

Synopsis:

The aim of this study was to investigate the insulin resistance and adipocytes factors in patients with Type 2 diabetes. The results of stepwise regression analysis showed that resistin, TNF-α and FFA were significantly associated with insulin resistance index (IRI).

ABSTRACT

Objective: Thirty cases of non-obese patients with type 2 diabetes, 30 cases of obese patients with type 2 diabetes and 30 cases of healthy controls were selected to detect the levels of serum resistin, TNF-α, FFA, fasting blood glucose, fasting insulin, total cholesterol and triglycerides.

Received:

12 Dec, 2014

Accepted:

23 Mar, 2015

PDF Attachment:

li_et_al-insulin_resistance_and_adipocytes_factors.pdf

Journal Sections:

Keywords:

tumor necrosis factor

Journal Authors:

e-Published: 15 Jun, 2017

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

The Urinary Levels of Some Essential and Toxic Metals in Type 2 Diabetic Patients and Non-diabetic Healthy Control Human Subjects

DOI:

10.7727/wimj.2016.134

Synopsis:

Elevated level of metals in blood is reflected in urine of the human diabetic subjects. As an increased urinary excretion of metals causes decrease in blood plasma level of that particular metal and vice versa. Toxic metals such as Pb may have a role to induce renal tubular dysfunction in diabetic patients. Subsequently, dysfunctional kidneys may become a potential source for the loss of several essential TE through urine voiding rather than their retention in blood plasma /serum in order to retain the homeostasis of blood and other tissues.

ABSTRACT

Objective: To compare the levels of some selected essential and toxic metals in type 2 diabetic (T2D) patients and non-diabetic (ND) healthy controls. Furthermore, study aims to evaluate the possible interrelationship of metals in urine of type 2 diabetic (T2D) patients and non-diabetic (ND) healthy controls.

Received:

31 Mar, 2016

Accepted:

29 Nov, 2016

PDF Attachment:

khan_et_al-derangement_of_urinary_metals_in_diabetes.pdf

Journal Sections:

Original Articles

Keywords:

Type 2 diabetes

urine

Essential and toxic metals

Journal Authors:

e-Published: 06 Dec, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

A Case of Primary Systemic Amyloidosis and Type 2 Diabetes Presenting with Nephrotic Syndrome and Recurrent Periorbital Purpura

DOI:

10.7727/wimj.2015.379

ABSTRACT

Received:

06 Jul, 2015

Accepted:

10 Sep, 2015

PDF Attachment:

yin_et_al-systemic_amyloidosis_with_type_2_diabetes.pdf

Journal Sections:

Case Reports

Keywords:

Electron microscopy

nephrotic syndrome

primary systemic amyloidosis

recurrent periorbital purpura

Journal Authors:

e-Published: 15 Feb, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Therapeutic Effects of Tanshinone IIA towards Early Renal Damage in Patients with Type 2 Diabetes

DOI:

10.7727/wimj.2015.376

Synopsis:

There is a significant improvement in microalbuminuria, serum β2-croglobulin, urine B2-microglobulin and serum cystatin C by Tanshinone IIA in the management of early renal damage in patients with type 2 diabetes. Hence, Tanshinone 11A might alleviate early renal damage from diabetic nephropathy.

ABSTRACT

Aims: The present study aims to explore the role of Tanshinone IIA administration on the protective effect of early renal damage in patients with type 2 diabetes.

Received:

06 Jul, 2015

Accepted:

10 Sep, 2015

PDF Attachment:

han_et_al-tanshinone_iia_ameliorates_early_diabetic_nephropathy.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 11 Feb, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Association of the KCNJ11 Variant E23K with Type 2 Diabetes in Indo-Trinidadians

Issue:

Vol 60, Issue 6 (2011)

Pages:

604–7

Synopsis:

Research has implicated Kir 6.2 (KCNJ11) as a diabetes susceptibility gene. Positive risk correlation has been detected in European and Asian populations. A subset of Trinidadians was screened, revealing novel variants in this gene and positive disease association in Indo-Trinidadians.

ABSTRACT

Objective: To examine the effect of genetic variation in KCNJ11 on the risk of Type 2 diabetes mellitus in Trinidadians.

PDF Attachment:

dr_lg_boodram.qxd_.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 03 Feb, 2014

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An Assessment of the Risk Factors for Type 2 Diabetes among Women in Rural Jamaica

Issue:

Vol 61, Issue 8 (2012)

DOI:

10.7727/wimj.2011.166

Pages:

809–13

Synopsis:

Risk factors for Type 2 diabetes among women in rural Jamaica were assessed using the behavioural risk factor surveillance system (BRFSS) and body mass index (BMI). A comprehensive plan targeting women to reduce risk for Type 2 diabetes is recommended.

ABSTRACT

PDF Attachment:

dr_gc_bryan_wimj_november.qxd_.pdf

Journal Sections:

Original Articles

Keywords:

Type 2 diabetes

Behavioural Risk Factor Surveillance System (BRFSS)

diabetes awareness campaigns

risk factors

rural Jamaican women

Journal Authors: