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The Effects of Low-dose Bisoprolol on the Renin-Angiotensin-Aldosterone System and Ventricular Remodelling



Objective: To explore the effects of low-dose bisoprolol on the renin-angiotensin-aldosterone system (RAAS) and ventricular remodelling.

Methods: Eighty patients who were initially diagnosed with hypertension and left ventricular hypertrophy were investigated for the renin, angiotensin II and aldosterone levels in plasma and the thickness of the left ventricular posterior wall, interventricular septum and left ventricular mass index after 24 weeks of treatment with oral bisoprolol. The results were then compared with the readings before treatment.

Results: After treatment, all of the indices mentioned above were compared with those before treatment and were found to be significantly lower. The differences were significant (p < 0.05).

Conclusion: Bisoprolol can inhibit the RAAS and reverse ventricular remodelling.

22 Aug, 2016
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e-Published: 09 Jul, 2018
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