Synopsis:
This study was to investigate the protective effect of extracts from Polygonum hydropiper on experimentally-induced AGML in mice. The findings showed that the extract could distinctly reduce the acute gastric mucosal damage, and these are closely associated with antioxidant effect. The extracts enhanced the activities of antioxidative enzymes SOD and GSH-Px and decreased the level of MDA in the serum and gastric tissues. In addition, the extracts increased the production of PGE2 and decreased the NO level in gastric tissues.