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oxidative stress

Protective Effects of Extracts from Polygonum Hydropiper L on Ethanol-Induced Acute Gastric Mucosal Lesions

DOI: 
10.7727/wimj.2016.503
Synopsis: 
This study was to investigate the protective effect of extracts from Polygonum hydropiper on experimentally-induced AGML in mice. The findings showed that the extract could distinctly reduce the acute gastric mucosal damage, and these are closely associated with antioxidant effect. The extracts enhanced the activities of antioxidative enzymes SOD and GSH-Px and decreased the level of MDA in the serum and gastric tissues. In addition, the extracts increased the production of PGE2 and decreased the NO level in gastric tissues.

ABSTRACT

Accepted: 
30 Mar, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 01 May, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Thymoquinone Reduces Oxidative and Nitrosative Stress in Tongue Tissue of Rats Exposed to Total Cranial Irradiation

Issue: 
DOI: 
10.7727/wimj.2015.297
Pages: 
543-50
Synopsis: 
This is the first study that investigates the effect of thymoquinone on the oxidant/antioxidant system in the irradiated tongue tissue of the rats.

ABSTRACT

Background: Head and neck cancer patients treated with radiotherapy suffer severe side effects during and following their treatment. Efforts to decrease toxicity of irradiation to normal tissue, organs and cells have led to searching for cytoprotective agent. Investigations for effective and non-toxic compounds with radioprotective capability led to increasing interest in antioxidant such as Thymoquinone (TQ).

Accepted: 
12 Jun, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 22 Mar, 2016

Vascular Endothelial Dysfunction Caused by Oxidative Stress is a Predictor Factor for Complications of Obstructive Sleep Apnea Syndrome

DOI: 
10.7727/wimj.2015.383
Synopsis: 
We aimed to determine oxidative imbalance and vascular endothelial dysfunction as suspects for complications of OSAS. We found both oxidative stress and vascular endothelial dysfunction lead to early development of atherosclerosis which may cause the life-threatening complications of OSAS.

ABSTRACT

Objective: Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of upper airway obstruction that occur during sleep which leads to cardiovascular, neurovascular and metabolic diseases. The mechanisms of complications in these patients are unclear. In this report, we aimed to determine the cause of oxidative imbalance in patients with OSAS and to evaluate the vascular endothelial dysfunction as a suspect for complications of the disease.

Accepted: 
10 Sep, 2015
Journal Sections: 
e-Published: 15 Feb, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Protective Effects of Curcumin against Formaldehyde-induced Renal Toxicity in Rats

DOI: 
10.7727/wimj.2015.385
Synopsis: 
We explored the protective effects of curcumin against renal injury induced by formaldehyde in rats and found that it improved the formaldehyde-induced renal degeneration.

ABSTRACT

Objectives: To explore the protective effects of curcumin against renal injury induced by formaldehyde in rats.

Accepted: 
10 Sep, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 15 Oct, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Ameliorative Effect of Zinc Oxide and Silver Nanoparticles on Antioxidant System in the Brain of Diabetic Rats

DOI: 
10.7727/wimj.2015.296
Synopsis: 
The effect of zinc oxide and silver nanoparticles on the brain of diabetic rats was investigated. It was concluded that Zinc oxide and silver nanoparticles protect the brain's tissue against the bad effects of free radicals by improving the brain antioxidant power.

ABSTRACT

Objective: The present study tests the ability of both zinc oxide (ZnONPs) and silver (SNPs) nanoparticles to ameliorate the oxidative stress resulted from diabetes in diabetic rats was tested in the present study.

Accepted: 
12 Jun, 2015
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 17 Aug, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Correlation of Cataract with Serum Lipids, Glucose and Antioxidant Activities: A Case-control Study

Issue: 
Pages: 
230–4
Synopsis: 
This paper compares lipids, fasting glucose and oxidative stress marker profiles in patients with cataract with healthy age/sex-matched controls. There are statistical differences between cases and controls in these categories.

ABSTRACT

Objective: The aim of this study is to evaluate the relationship between cataract development and serum lipids, glucose as well as antioxidants in a case-control study.

PDF Attachment: 
Journal Sections: 
e-Published: 21 Aug, 2013

Chelation Therapy with Desferrioxamine does not Normalize Ferritin Level but Attenuates Oxidative Damage and Improves Total Antioxidant Level in Malaysian Chinese β-thalassaemia Major Patients

Issue: 
Pages: 
3–8
Synopsis: 
Beta-thalassaemia major patients require monthly blood transfusions. Studies on the oxidant-antioxidant indices in patients on desferrioxamine-chelation or without chelation indicate that desferrioxamine chelation does not normalize ferritin level but attenuates oxidative damage and improves total antioxidant level in these patients.

ABSTRACT

PDF Attachment: 
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e-Published: 17 Oct, 2013

Status of Oxidative Stress and Antioxidant Levels in Smokers with Breast Cancer from Western Nepal

DOI: 
10.7727/wimj.2014.078
Synopsis: 
The blood glucose lowering potential of aqueous fruit extracts of the Jamaican plant species (Momordica charantia) was investigated in Sprague-Dawley rats. The extract showed no hypoglycaemic or antidiabetic activity. However, there was improvement in glucose tolerance of glucose-primed normoglycaemic rats during oral glucose tolerance test.

Objectives: Research indicates that oxidative stress induced by smoking plays a crucial role in breast cancer. In view of these reports, we aimed to study this relationship between smoking and oxidative stress in breast cancer patients from western region of Nepal.

Accepted: 
31 Jul, 2014
Journal Sections: 
Journal Authors: 
e-Published: 04 May, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Paraoxonase 1 Status in Keratoconus: A Preliminary Study of Activity and Polymorphism

Issue: 
DOI: 
10.7727/wimj.2011.044
Pages: 
569–73
Synopsis: 
Keratoconic patients have reduced paraoxonase activity, which suggests that keratoconic corneas are more susceptible to oxidative stress. Reduced paraoxonase activity and keratoconus status appear to be associated with ethnicity.

ABSTRACT

PDF Attachment: 
Journal Sections: 
e-Published: 24 Jan, 2013

Role of Reactive Oxygen Species and Advanced Glycation End Products in the Malfunctioning of Dental Implants

Issue: 
DOI: 
10.7727/wimj.2014.105
Pages: 
419–23
Synopsis: 
Pathogenesis of peri-implantitis remains largely unknown. In this study, we have used salivary and tissue samples of patients with peri-implantitis and have highlighted a significant role for oxidative stress and advanced glycation end products in the pathogenesis.

ABSTRACT 

Accepted: 
05 Jun, 2014
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 29 Apr, 2015

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