Meningitis is a common clinical syndrome of invasive pneumococcal disease and occurs in 23% of cases resulting in mortality and high morbidity among Jamaican children. Local seroepidemiological studies are urgently needed to inform national vaccine decisions. As an interim plan, policymakers should consider a risk-based strategy to vaccine prophylaxis that will ensure that high risk groups such as children with Sickle cell disease are offered currently available conjugate pneumococcal vaccines.