The study investigates the sexual health practices and constraints faced by persons involved in commercial sex in Guyana. The study only had syphilis in two (2.9%) of the five (7.1%) reactive VDRL cases indicated prior history of syphilis infection. It was also found that (54.3%) of participants always used condoms while (74.3%) did not use drugs and only 2.9% consumed alcohol every day. The participants had a fair KAP towards syphilis but few misconceptions exist. Stigma and discrimination was identify as the major constraint faced by the male sex workers and 97.1% of CSW indicated that they preferred giving up sex work.