The United Nations High Level Meeting (UNHLM) will be an historic event where world leaders will address the increasing global burden of non-communicable diseases (NCDs). Its mandate is ‘to address the prevention and control of non-communicable diseases worldwide, with a particular focus on developmental and other challenges, and social and economic impacts, particularly for developing countries’. The Caribbean has played a leadership role in convening the UNHLM and, as a region significantly impacted by the NCD epidemic, may potentially benefit from the meeting outcomes.