Rotaviruses have been a significant cause of dehydrating
gastroenteritis, contributing to infant morbidity and mortality
in Jamaica. We enrolled 1804 Jamaican infants in
the international randomized, placebo-controlled, pentavalent
(G1, G2, G3, G4 and P1) rotavirus vaccine trial.
This pentavalent vaccine was found to significantly
reduce rotavirus-attributable emergency room visits and
hospitalizations, without increasing the rates of intussusception
or other serious adverse events in Jamaican
infants.