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Parallel Assessment of Bone Mineral Density and RANKL/OPG Ratio in Saudi Females

Issue:

Vol 3, Issue 1 (2016)

DOI:

10.7727/wimjopen.2014.312

Pages:

1–9

Synopsis:

This cross-sectional study was conducted to measure the bone mineral density of 499 apparently healthy Saudi females aged 20–65 years using quantitative ultrasound method. It was extended to measure blood receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) among participants and identify possible associated risk factors for osteopaenia or osteoporosis among them.

ABSTRACT

Background: Osteoporosis is a significant risk factor for morbidity, and its high prevalence among Saudi women should be considered to be a public health problem. Quantitative ultrasound was recommended for bone mineral density (BMD) screening. Receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) and their ratio are critical for physiological bone remodelling, and related abnormalities may lead to several osteopathies.

Received:

October 16, 2014

Revised:

July 17, 2015

Accepted:

August 10, 2015

Published:

February 8, 2016

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